Comparison between intranasal dexmedetomidine and intranasal midazolam as premedication for brain magnetic resonance imaging in pediatric patients: A. Intranasal dexmedetomidine has been used an effective and safe alternative premedication to oral midazolam in children. At a dose of 2micrograms/kg. Background Intranasal dexmedetomidine, a well-tolerated and convenient treatment option, has been shown to induce a favorable.

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A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric dexmedetomixine Sedation nurses collected the data immediately before discharging the patient and documented the following: The mean age and weight of the non-DEX cohort was 3.

Sundaram and Dexmedetomidone reported similar results. Minimal change in heart rate and blood pressure were noted. Financial support and sponsorship Nil. In our study, the median sedation score at the time of cannulation was 4 3—6 for Group M compared with 3 3—5 for Group D [ Figure 4 ].

A comparison of four routes of administration. All subjects were informed dexmedettomidine the database and were given the opportunity to opt-out from being included before PSA initiation. This allows for administration of a small volume which is dispensed quickly. Please review our privacy policy. Median sedation scores for Groups M and D were 4 and 3, respectively [ Figure 4 ]. Table 2 Comparison of successful parental separation between the groups.


Optimal timing for the administration of intranasal dexmedetomidine for premedication in children.

Given this dose, this dexmedetomidien calmed and fell asleep in the stretcher within 20 minutes. Comparison of the nasal and intganasal routes. A successful sedation with IN DEX was determined by completion of the non-invasive study without any additional sedative medications required to maintain subject’s sedation.

Investigations conducted by Yuen et al. A double blind RCT. A comparative evaluation of intranasal dexmedetomidine and intranasal midazolam for premedication in children: Introduction The importance intranaswl procedural sedation and analgesia PSA for children undergoing procedures and imaging studies has led to an increase in demand for sedation outside of the operating room.

Conflicts of interest There are no conflicts of interest. On the day of the non-invasive procedure, the physician providing the sedation evaluated each subject.

Results The demographic profile was comparable between the two groups [ Table 1 ]. High dose dexmedetomidine as the sole sedative for pediatric mri.

It is thought provoking and makes me consider using it in higher doses. There has been increasing interest in the clinical application of dexmedetomidine in the pediatric population. Int J Clin Pharmacol Ther.

Optimal timing for the administration of intranasal dexmedetomidine for premedication in children.

A dexmedstomidine analysis of procedure times found no statistical difference in subjects who had received additional IN midazolam compared to those given Ddxmedetomidine DEX alone; however, the sample size lacked adequate power.


Use in MRI Evidence supports the use of dexmedetomidine for sedation in mechanically ventilated adult patients. Correspondence Natalie Behrle, MD, ude. Discussion There are an increasing number of published reports describing the use of DEX; however, there is little agreement regarding the dose and route of administration. Comparison of two different intranasal doses of dexmedetomidine in children for magnetic resonance imaging sedation.

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A randomized study of intranasal vs. Dexmedetomidinf Administration of Dexmedetomidine as a Preanesthetic in Children. However, few studies have reported on the intranasal use of dexmedetomidine in radiological procedures.

J Anaesthesiol Clin Pharmacol. The difference in onset time was statistically significant with early onset in midazolam.

Premedication with midazolam in children. Sixteen of 30 children Open in a separate window. IN dexmedetomidine may be used for non-invasive pediatric procedural sedation. A comparative evaluation of intranasal dexmedetomidine, midazolam and ketamin for their sedative and analgesic properties: Thank you for sharing your dexmedeomidine.

The mean age and weight were 2.