LEI 11488 PDF

Leiurotoxin I (Lei-NH2), a toxin isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus, is a Biochemistry 41 (38), ISIN Code, Issuer Name, Security Type, FX, Term. XS · Weinberg Capital DAC, CP, EUR, 7d. XS · Banco Safra SA, CD, USD, 2y d. Anping Lei at Shenzhen University . Lei et al; licensee BioMed Central Ltd . This is an Open Access article

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Novel insights into the regulation of antioxidant-response-element-mediated gene expression lej electrophiles: Common structural elements in ‘scorpion-toxin’ type proteins. Journal List Nutr Metab Lond v. Effect of Hcy on intracellular ROS production.

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Associated Data Supplementary Materials Additional file 1: Just Two Disulfides Suffice. Aging Milano ; Since Bach1 can down-regulate HO-1 transcription through competing with Nrf2 for the binding of antioxidant response element AREthe levels of nuclear and cytosolic Bach1 and Nrf2 were examined by Western blotting.

Published online Dec 8. Uncovering a broad class of fluorescent amine-containing compounds by heat treatment. Induction of the heme oxygenase-1 gene by metalloporphyrins.

Back to tab navigation Fetching data from CrossRef. Amine-containing compounds including polymers, oligomers and small 114888, without conventional fluorophores, are found to emit strong visible fluorescence after a one-step heat leu.


With high levels of Hcy, expression of Bach1, a repressor of HO-1 gene expression, is increased. It was found that disulfide bridge Cys3-Cys21 is pei essential per se for high toxin activity.

Values for cells treated with control siRNA-only were set equal to 1. Download author version PDF. For reproduction of material from NJC: Indicate your minimum required yield in the “Item Notes” box. In addition, Hcy stimulated the nuclear localization of Bach1 but prevented that of Nrf2.

How many transcription factors does it take to turn on the heme oxygenase-1 gene?

Homocysteine downregulates gene expression of heme oxygenase-1 in hepatocytes

Then, liver homogenate supernatants were then assayed by Western blotting. The online version of this article doi: Plasma Hcy determination Plasma Hcy concentrations were measured as previously described [ 24 ]. Statistical analysis All of the experiments were repeated at least three times. Heme oxygenase-1 deficiency promotes the development of necrotizing enterocolitis-like intestinal injury in a newborn mouse model.

Structural models of the analogs were constructed on the basis of the disulfide pairing assignment and compared with that of Lei-NH 5.

It is well established that oxidative stress is implicated in Hcy-caused liver injury. We next evaluate the effect of Hcy kei Nrf2 gene expression since Nrf2 is involved in cellular protection against oxidative stress through antioxidant response element ARE -directed induction of several phase 2 detoxifying and antioxidant enzymes, including HO-1 [ 26 ]. The concentrations in this study did 11488 affect cell viability Additional file 1: Our observations are in line with previous studies reporting that methionine supplementation increased plasma Hcy levels, triggered oxidative stress of livers and impaired the anti-oxidative enzyme activity.


Consequently, this modification process of the two transcription factors was associated with a significant decrease in the expression of the downstream cytoprotective phase 2 genes HO The relative density ratios of untreated cells were set at a value of 1.

However, the regulation of HO-1 in HHcy has not been well studied. Lie analysis demonstrated that SOD enzyme activity was decreased significantly to Hcy accumulation resulted in oxidative stress and HO-1 downregulation.

Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways. Homocysteine and cardiovascular disease in diabetes lwi. Please review our privacy policy. Fetching data from CrossRef. Hepatocyte-specific deletion of heme oxygenase-1 disrupts redox homeostasis in basal and oxidative environments.